Research Faculty

Anupama Sathyamurthy

India Alliance Intermediate Career Fellow

Phone : +91 80 2293 2904
E-Mail : anupamasathy[at]iisc.ac.in
SensationToAction lab website

Research Areas

Neural substrates of motor control

Research Details

It is the fundamental need for movement that has shaped the organization of the nervous system – it is designed to constantly sense and surveil the environment and the internal state and promptly use this information to implement motor responses that benefit survival and well-being. In humans, the ability to generate stimulus appropriate motor responses is often diminished in the elderly and in those with injuries or disorders of the nervous system, severely reducing quality of life. However, very little is known about the etiology of many motor disorders owing to lack of sufficient understanding of the neural substrates that underlie sensorimotor control in health. The goal of our lab is to dissect the neural mechanisms by which circuits nucleated in the spinal cord bring about motor behaviors both in health and in disease. Specifically, we use genetic strategies in rodents to label and manipulate local, descending, and ascending spinal networks to reveal how sensory information gets processed at subsequent nodes in the circuit leading to effective and diverse motor outcomes.

Publications

Barik A, Sathyamurthy A, Thompson J, Seltzer M, Levine AJ, Chesler AT, (2021), A spinoparabrachial -circuit defined by Tacr1 expression drives pain, Elife, 10, e61135.

Sathyamurthy A, Barik A, Dobrott CI, Matson KJE, Stoica S, Pursley R, Chesler AT, Levine AJ, (2020), Cerebellospinal neurons regulate motor performance and motor learning, Cell Reports, 31(6):, 107595

Dobrott C, Sathyamurthy A, Levine AJ, (2019), Decoding cell type diversity within the spinal cord, Current Opinion in Physiology, 8, 1-6

Zhang H, Sathyamurthy A, Liu F, Li L, Zhang L, Dong Z, Cui W, Sun X, Zhao K, Wang H, Ho HH, Xiong WC, Mei L, (2019), Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice, Elife, 8, e45303

Matson KJE, Sathyamurthy A, Johnson KR, Kelly MC, Kelley MW, Levine AJ, (2018), Isolation of adult spinal cord nuclei for massively parallel single-nucleus RNA sequencing, J Vis Exp, (140)

Sathyamurthy A*, Johnson KR*, Matson KJE, Dobrott CI, Li L, Ryba AR, Bergmann TB, Kelly MC, Kelley MW, Levine AJ, (2018), Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior, Cell Rep, 22(8):, 2216-2225 (* authors contributed equally).

Barik A, Li L, Sathyamurthy A, Xiong WC, Mei L, (2016), Schwann Cells in Neuromuscular Junction Formation and Maintenance, Journal of Neuroscience, 36(38), 9770-81

Sun XD, Li L, Liu F, Huang ZH, Bean JC, Jiao HF, Barik A, Kim SM, Wu H, Shen C, Tian Y, Lin TW, Bates R, Sathyamurthy A, Chen YJ, Yin DM, Xiong L, Lin HP, Hu JX, Li BM, Gao TM, Xiong WC, Mei L, (2016), Lrp4 in astrocytes modulates glutamatergic transmission, Nature neuroscience, 19(8), 1010-1018

Wu H, Barik A, Lu Y, Shen C, Bowman A, Li L, Sathyamurthy A, Lin TW, Xiong WC, Mei L, (2015), Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation, Elife, 4, e07266.

Sathyamurthy A, Yin DM, Barik A, Shen C, Bean JC, Figueiredo D, She JX, Xiong WC, Mei L, (2015), ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination, Development , 142(3), 522-532.

Yin DM, Chen YJ, Liu S, Jiao H, Shen C, Sathyamurthy A, Lin TW, Xiong WC, Li BM, Mei L, Bergson C, (2015), Calcyon stimulates neuregulin 1 maturation and signaling, Molecular psychiatry, 20, 1251-1260.

Barik A, Lu Y, Sathyamurthy A, Bowman A, Shen C, Li L, Xiong WC, Mei L, (2014), LRP4 is critical for neuromuscular junction maintenance, J Neurosci, 34(42), 13892-905.

Bean JC, Lin TW, Sathyamurthy A, Liu F, Yin DM, Xiong WC, Mei L, (2014), Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain, Journal of Neuroscience, 34(40), 13549-13566.

Yin DM, Sun XD, Bean JC, Lin TW, Sathyamurthy A, Xiong WC, Gao TM, Chen YJ, Mei L, (2013), Regulation of spine formation by ErbB4 in PV-positive interneurons, Journal of Neuroscience, 33(49), 19295-19303.

Yin DM, Chen YJ, Lu YS, Bean JC, Sathyamurthy A, Shen C, Liu X, Lin TW, Smith CA, Xiong WC, Mei L, (2013), Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1, Neuron, 78(4), 644-657.

Yin DM, Chen YJ, Sathyamurthy A, Xiong WC, (2012), Synaptic dysfunction in schizophrenia, Synaptic Plasticity, 493-516.