{"id":2202,"date":"2023-08-07T13:19:31","date_gmt":"2023-08-07T13:19:31","guid":{"rendered":"https:\/\/cns.iisc.ac.in\/sray\/?p=2202"},"modified":"2025-06-28T05:54:36","modified_gmt":"2025-06-28T05:54:36","slug":"aging-disorders","status":"publish","type":"post","link":"https:\/\/cns.iisc.ac.in\/sray\/aging-disorders\/","title":{"rendered":"Aging and Mental Disorders"},"content":{"rendered":"\n<p>We collected EEG data from a large cohort (350 recordings from 279 subjects) of elderly subjects (&gt;50 years) while they viewed visual stimuli that induced gamma oscillations. This entire dataset and associated codes are available freely.<\/p>\n\n\n\n<p>Data: <a href=\"https:\/\/osf.io\/ebryn\/\">https:\/\/osf.io\/ebryn\/<\/a><\/p>\n\n\n\n<p>Codes: <a href=\"https:\/\/github.com\/supratimray\/TLSAEEGProjectPrograms\">https:\/\/github.com\/supratimray\/TLSAEEGProjectPrograms<\/a> <\/p>\n\n\n\n<p>Recording method: (Murty and Ray, 2022, Bio-protocol).<\/p>\n\n\n\n<p><strong>Research Highlights<\/strong><\/p>\n\n\n\n<ul><li>Gamma oscillations weaken with age in healthy elderly subjects (Murty et al., 2020, Neuroimage)<\/li><li>Gamma oscillations are weaker in subjects with Mild Cognitive Impairment (MCI) and Alzheimer\u2019s Disease (AD) as compared to their age and gender matched controls (Murty et al., 2021, eLife).<\/li><li>Gamma oscillations remain remarkably consistent across recordings separated by more than one year (Kumar et al., 2022, Cerebral Cortex Communications).<\/li><li>Gamma and alpha oscillations show distinct patterns of functional connectivity changes with aging and mental disorders (Kumar and Ray, 2023, European Journal of Neuroscience)<\/li><li>Slope of the power spectral density flattens below 150 Hz but also steepens at higher frequencies with healthy aging (Aggarwal and Ray, 2023, Cerebral Cortex Communications).<\/li><li>Stimulus-induced gamma sources reduce in power but not in spatial extent with healthy aging in human EEG (Biswas, Kumar, Sharma, and Ray, 2025, European Journal of Neuroscience).<\/li><li>Changes in Higuchi\u2019s fractal dimension across age in healthy human EEG are anti-correlated with changes in oscillatory power and 1\/f slope (Aggarwal and Ray, 2025, European Journal of Neuroscience).<\/li><\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We collected EEG data from a large cohort (350 recordings from 279 subjects) of elderly subjects (&gt;50 years) while they viewed visual stimuli that induced gamma oscillations. This entire dataset and associated codes are available&#8230;<\/p>\n","protected":false},"author":6,"featured_media":2210,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":""},"categories":[30],"tags":[],"_links":{"self":[{"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/posts\/2202"}],"collection":[{"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/comments?post=2202"}],"version-history":[{"count":7,"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/posts\/2202\/revisions"}],"predecessor-version":[{"id":2377,"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/posts\/2202\/revisions\/2377"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/media\/2210"}],"wp:attachment":[{"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/media?parent=2202"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/categories?post=2202"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cns.iisc.ac.in\/sray\/wp-json\/wp\/v2\/tags?post=2202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}